American researchers completed a single-center analysis of outcomes for twenty women who underwent uterine transplantation in 2024. The study found that seventy percent of these women were able to give birth to at least one child.
Subsequently, Caitlin O'Neil from the University of Pennsylvania conducted a larger prospective cohort analysis. It covered sixty women across four American clinical centers and the period from February 2016 to December 2025, thereby confirming the initial findings.
The most common reason for uterine transplantation was Mayer-Rokitansky-Küster-Hauser syndrome, characterized by the congenital absence of the uterus while retaining functional ovaries, which was identified in 52 patients. Other indications included prior hysterectomy (in six patients), dysfunctional uterus, and androgen insensitivity syndrome (in one patient).
It is important to note that in seventy percent of cases, living donors were used. The results of this analysis were officially published in the scientific journal Obstetrics & Gynecology.
